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#374356
Tue 10 May 2016 05:27:PM
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Joined: Feb 2001
Posts: 381,903
Launch Director
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OP
Launch Director
Joined: Feb 2001
Posts: 381,903 |
A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors. A new study reveals that hyaluronic acid is primarily responsible for generating elevated gel-fluid pressures in tumors. In a mouse model of pancreatic cancer, treatment with an enzyme that breaks down hyaluronic acid normalized fluid pressure in tumors and allowed vessels to re-expand, thereby overcoming a major barrier to drug delivery. Source: Why cancer drugs can't take the pressure
David Cottle
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