There is broad scientific interest in understanding the origin of the catalytic power of enzymes on a molecular level. While hypotheses have been put forward using experimental and computational approaches, they must be examined critically. Researchers now present a critical review of the dynamical concept -- time-dependent coupling between protein conformational motions and chemical reactions -- that explores all reasonable definitions of what does and does not qualify as a dynamical effect.

Source: Exploring the Mystery of How Enzymes Work via Simulations