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#453130
Tue 27 Feb 2018 07:41:PM
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Joined: Feb 2001
Posts: 381,903
Launch Director
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OP
Launch Director
Joined: Feb 2001
Posts: 381,903 |
Brain development depends on axons migrating from one location to another by haptotaxis. L1-CAM is responsible for detecting laminin in the environment to regulate the haptotaxis. Scientists have discovered a new mechanism in which L1-CAM grips and slips on laminin to direct axon to its final destination. Loss of this mechanism corresponded with mutations in the L1-CAM protein of CRASH syndrome patients. Source: Axons grip and slip their way around the brain
David Cottle
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